Molecular epidemiology of HIV in Ghana: Dominance of CRF02_AG
Identifieur interne : 000F49 ( Main/Exploration ); précédent : 000F48; suivant : 000F50Molecular epidemiology of HIV in Ghana: Dominance of CRF02_AG
Auteurs : Lucia Fischetti [Royaume-Uni] ; Ohene Opare-Sem [Ghana] ; Daniel Candotti [Royaume-Uni] ; Francis Sarkodie [Ghana] ; Helen Lee [Royaume-Uni] ; Jean Pierre Allain [Royaume-Uni]Source :
- Journal of Medical Virology [ 0146-6615 ] ; 2004-06.
Descripteurs français
- KwdFr :
- ARN viral (isolement et purification), Adulte, Adulte d'âge moyen, Analyse de regroupements, Analyse de séquence d'ADN, Données de séquences moléculaires, Femelle, Ghana (épidémiologie), Gènes env, Gènes gag (génétique), Gènes pol, Gènes viraux, Génotype, Humains, Infections à VIH (virologie), Infections à VIH (épidémiologie), Mâle, Phylogénie, RT-PCR, Recombinaison génétique, VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (isolement et purification), VIH-2 (Virus de l'Immunodéficience Humaine de type 2) (), VIH-2 (Virus de l'Immunodéficience Humaine de type 2) (génétique), VIH-2 (Virus de l'Immunodéficience Humaine de type 2) (isolement et purification), Virémie, Épidémiologie moléculaire.
- MESH :
- génétique : Gènes gag, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), VIH-2 (Virus de l'Immunodéficience Humaine de type 2).
- isolement et purification : ARN viral, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), VIH-2 (Virus de l'Immunodéficience Humaine de type 2).
- virologie : Infections à VIH.
- épidémiologie : Ghana, Infections à VIH.
- Pascal (Inist)
- Wicri :
- geographic : Adulte, Adulte d'âge moyen, Analyse de regroupements, Analyse de séquence d'ADN, Données de séquences moléculaires, Femelle, Ghana, Gènes env, Gènes pol, Gènes viraux, Génotype, Humains, Mâle, Phylogénie, RT-PCR, Recombinaison génétique, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), VIH-2 (Virus de l'Immunodéficience Humaine de type 2), Virémie, Épidémiologie moléculaire.
- topic : épidémiologie.
English descriptors
- KwdEn :
- AIDS, Adult, Aids patients, Asymptomatic, Asymptomatic candidate blood donors, Asymptomatic candidate donors, Asymptomatic population, Biosystem, Carr, Clinical aids, Clinical status, Cluster Analysis, Cornelissen, Delaporte, Double infection, Double infections, Dual infections, Epidemiology, Female, Genes, Viral, Genes, env, Genes, gag (genetics), Genes, pol, Genetic diversity, Genome, Genotype, Ghana, Ghana (epidemiology), HIV Infections (epidemiology), HIV Infections (virology), HIV-1 (classification), HIV-1 (genetics), HIV-1 (isolation & purification), HIV-2 (classification), HIV-2 (genetics), HIV-2 (isolation & purification), Heteroduplex mobility assay, Heyndrickx, Human immunodeficiency virus, Human virus type, Humans, Hxb2, Hxb2 positions, Inner primers, Ishikawa, Janssens, Kumasi, Male, Mboup, Mccutchan, Middle Aged, Molecular Epidemiology, Molecular Sequence Data, Molecular data, Molecular distribution, Molecular epidemiology, Molecular groups, Montavon, Nucleic acid, Outer primers, Peeters, Phylogenetic, Phylogenetic analysis, Phylogeny, Present study, Primer, Protease gene, RNA, Viral (isolation & purification), Recombinant, Recombinant form, Recombinant forms, Recombinant strains, Recombination, Recombination, Genetic, Reference strains, Retrovirus, Reverse Transcriptase Polymerase Chain Reaction, Sample collection, Second round, Sequence Analysis, DNA, Sequencing, Subtype, Subtypes, Total population, Vergne, Viral, Viremia, West africa, West african countries.
- MESH :
- chemical , isolation & purification : RNA, Viral.
- geographic , epidemiology : Ghana.
- classification : HIV-1, HIV-2.
- epidemiology : HIV Infections.
- genetics : Genes, gag, HIV-1, HIV-2.
- isolation & purification : HIV-1, HIV-2.
- virology : HIV Infections.
- Teeft :
- Adult, Aids patients, Asymptomatic, Asymptomatic candidate blood donors, Asymptomatic candidate donors, Asymptomatic population, Biosystem, Carr, Clinical aids, Clinical status, Cluster Analysis, Cornelissen, Delaporte, Double infection, Double infections, Dual infections, Epidemiology, Female, Genes, Viral, Genes, env, Genes, pol, Genetic diversity, Genome, Genotype, Ghana, Heteroduplex mobility assay, Heyndrickx, Human virus type, Humans, Hxb2, Hxb2 positions, Inner primers, Ishikawa, Janssens, Kumasi, Male, Mboup, Mccutchan, Middle Aged, Molecular Epidemiology, Molecular Sequence Data, Molecular data, Molecular distribution, Molecular epidemiology, Molecular groups, Montavon, Nucleic acid, Outer primers, Peeters, Phylogenetic, Phylogenetic analysis, Phylogeny, Present study, Primer, Protease gene, Recombinant, Recombinant form, Recombinant forms, Recombinant strains, Recombination, Recombination, Genetic, Reference strains, Retrovirus, Reverse Transcriptase Polymerase Chain Reaction, Sample collection, Second round, Sequence Analysis, DNA, Sequencing, Subtype, Subtypes, Total population, Vergne, Viral, Viremia, West africa, West african countries.
Abstract
Recent studies showed the importance of CRF02_AG in West Africa, although the clinical relevance of these recombinant forms of HIV remains unknown. The present study aimed at determining the molecular diversity of HIV in Ghana and investigating the possible epidemiologic advantage of recombinant HIV‐1. Plasma samples collected in 1999–2002 from two populations of HIV infected individuals (144 asymptomatic candidate blood donors and 169 AIDS patients) were studied and 249 of them were molecularly characterised in gag, pol, and env regions. Five molecular groups were identified: strains clustering with CRF02_AG in all regions (147/249 or 59%), recombinant strains clustering with CRF02_AG in one or two regions (50/249 or 20%), other subtypes, pure or recombinant, but not involving CRF02_AG (37/249 or 15%), HIV‐2 (11/249 or 4.5%), and double infections (4/249 or 1.5%). There was no significant difference in the distribution of HIV‐1 recombinant strains according to clinical presentation. No evidence of a significant increase in CRF02_AG prevalence between 1999 and 2002 was found. Irrespective of clinical condition, CRF02_AG is the predominant molecular form of HIV‐1 in Kumasi, Ghana. J. Med. Virol. 73:158–166, 2004. © 2004 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jmv.20070
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000036
- to stream Istex, to step Curation: 000036
- to stream Istex, to step Checkpoint: 000525
- to stream PubMed, to step Corpus: 000228
- to stream PubMed, to step Curation: 000228
- to stream PubMed, to step Checkpoint: 000228
- to stream Ncbi, to step Merge: 000148
- to stream Ncbi, to step Curation: 000148
- to stream Ncbi, to step Checkpoint: 000148
- to stream Main, to step Merge: 000F96
- to stream PascalFrancis, to step Corpus: 000109
- to stream PascalFrancis, to step Curation: 000037
- to stream PascalFrancis, to step Checkpoint: 000096
- to stream Main, to step Merge: 001032
- to stream Main, to step Curation: 000F49
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Molecular epidemiology of HIV in Ghana: Dominance of CRF02_AG</title><author><name sortKey="Fischetti, Lucia" sort="Fischetti, Lucia" uniqKey="Fischetti L" first="Lucia" last="Fischetti">Lucia Fischetti</name></author><author><name sortKey="Opare Em, Ohene" sort="Opare Em, Ohene" uniqKey="Opare Em O" first="Ohene" last="Opare-Sem">Ohene Opare-Sem</name></author><author><name sortKey="Candotti, Daniel" sort="Candotti, Daniel" uniqKey="Candotti D" first="Daniel" last="Candotti">Daniel Candotti</name></author><author><name sortKey="Sarkodie, Francis" sort="Sarkodie, Francis" uniqKey="Sarkodie F" first="Francis" last="Sarkodie">Francis Sarkodie</name></author><author><name sortKey="Lee, Helen" sort="Lee, Helen" uniqKey="Lee H" first="Helen" last="Lee">Helen Lee</name></author><author><name sortKey="Allain, Jean Pierre" sort="Allain, Jean Pierre" uniqKey="Allain J" first="Jean Pierre" last="Allain">Jean Pierre Allain</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:BEDA12C23AA0858C475661CF3A8D230FF53EADD5</idno><date when="2004" year="2004">2004</date><idno type="doi">10.1002/jmv.20070</idno><idno type="url">https://api.istex.fr/document/BEDA12C23AA0858C475661CF3A8D230FF53EADD5/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000036</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000036</idno><idno type="wicri:Area/Istex/Curation">000036</idno><idno type="wicri:Area/Istex/Checkpoint">000525</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000525</idno><idno type="wicri:doubleKey">0146-6615:2004:Fischetti L:molecular:epidemiology:of</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:15122787</idno><idno type="wicri:Area/PubMed/Corpus">000228</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000228</idno><idno type="wicri:Area/PubMed/Curation">000228</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000228</idno><idno type="wicri:Area/PubMed/Checkpoint">000228</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000228</idno><idno type="wicri:Area/Ncbi/Merge">000148</idno><idno type="wicri:Area/Ncbi/Curation">000148</idno><idno type="wicri:Area/Ncbi/Checkpoint">000148</idno><idno type="wicri:doubleKey">0146-6615:2004:Fischetti L:molecular:epidemiology:of</idno><idno type="wicri:Area/Main/Merge">000F96</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:04-0412496</idno><idno type="wicri:Area/PascalFrancis/Corpus">000109</idno><idno type="wicri:Area/PascalFrancis/Curation">000037</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000096</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000096</idno><idno type="wicri:doubleKey">0146-6615:2004:Fischetti L:molecular:epidemiology:of</idno><idno type="wicri:Area/Main/Merge">001032</idno><idno type="wicri:Area/Main/Curation">000F49</idno><idno type="wicri:Area/Main/Exploration">000F49</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Molecular epidemiology of HIV in Ghana: Dominance of CRF02_AG</title><author><name sortKey="Fischetti, Lucia" sort="Fischetti, Lucia" uniqKey="Fischetti L" first="Lucia" last="Fischetti">Lucia Fischetti</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Opare Em, Ohene" sort="Opare Em, Ohene" uniqKey="Opare Em O" first="Ohene" last="Opare-Sem">Ohene Opare-Sem</name><affiliation wicri:level="1"><country xml:lang="fr">Ghana</country><wicri:regionArea>Komfo Anokye Teaching Hospital, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Candotti, Daniel" sort="Candotti, Daniel" uniqKey="Candotti D" first="Daniel" last="Candotti">Daniel Candotti</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>National Blood Service, Cambridge Blood Centre, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Sarkodie, Francis" sort="Sarkodie, Francis" uniqKey="Sarkodie F" first="Francis" last="Sarkodie">Francis Sarkodie</name><affiliation wicri:level="1"><country xml:lang="fr">Ghana</country><wicri:regionArea>Komfo Anokye Teaching Hospital, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Helen" sort="Lee, Helen" uniqKey="Lee H" first="Helen" last="Lee">Helen Lee</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Allain, Jean Pierre" sort="Allain, Jean Pierre" uniqKey="Allain J" first="Jean Pierre" last="Allain">Jean Pierre Allain</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge</wicri:cityArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Haematology, Division of Transfusion Medicine, East Anglia Blood Centre, Long Road, Cambridge CB2 2PT</wicri:regionArea><wicri:noRegion>Cambridge CB2 2PT</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">73</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="158">158</biblScope><biblScope unit="page" to="166">166</biblScope><biblScope unit="page-count">9</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2004-06">2004-06</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term><term>Adult</term><term>Aids patients</term><term>Asymptomatic</term><term>Asymptomatic candidate blood donors</term><term>Asymptomatic candidate donors</term><term>Asymptomatic population</term><term>Biosystem</term><term>Carr</term><term>Clinical aids</term><term>Clinical status</term><term>Cluster Analysis</term><term>Cornelissen</term><term>Delaporte</term><term>Double infection</term><term>Double infections</term><term>Dual infections</term><term>Epidemiology</term><term>Female</term><term>Genes, Viral</term><term>Genes, env</term><term>Genes, gag (genetics)</term><term>Genes, pol</term><term>Genetic diversity</term><term>Genome</term><term>Genotype</term><term>Ghana</term><term>Ghana (epidemiology)</term><term>HIV Infections (epidemiology)</term><term>HIV Infections (virology)</term><term>HIV-1 (classification)</term><term>HIV-1 (genetics)</term><term>HIV-1 (isolation & purification)</term><term>HIV-2 (classification)</term><term>HIV-2 (genetics)</term><term>HIV-2 (isolation & purification)</term><term>Heteroduplex mobility assay</term><term>Heyndrickx</term><term>Human immunodeficiency virus</term><term>Human virus type</term><term>Humans</term><term>Hxb2</term><term>Hxb2 positions</term><term>Inner primers</term><term>Ishikawa</term><term>Janssens</term><term>Kumasi</term><term>Male</term><term>Mboup</term><term>Mccutchan</term><term>Middle Aged</term><term>Molecular Epidemiology</term><term>Molecular Sequence Data</term><term>Molecular data</term><term>Molecular distribution</term><term>Molecular epidemiology</term><term>Molecular groups</term><term>Montavon</term><term>Nucleic acid</term><term>Outer primers</term><term>Peeters</term><term>Phylogenetic</term><term>Phylogenetic analysis</term><term>Phylogeny</term><term>Present study</term><term>Primer</term><term>Protease gene</term><term>RNA, Viral (isolation & purification)</term><term>Recombinant</term><term>Recombinant form</term><term>Recombinant forms</term><term>Recombinant strains</term><term>Recombination</term><term>Recombination, Genetic</term><term>Reference strains</term><term>Retrovirus</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Sample collection</term><term>Second round</term><term>Sequence Analysis, DNA</term><term>Sequencing</term><term>Subtype</term><term>Subtypes</term><term>Total population</term><term>Vergne</term><term>Viral</term><term>Viremia</term><term>West africa</term><term>West african countries</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (isolement et purification)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de regroupements</term><term>Analyse de séquence d'ADN</term><term>Données de séquences moléculaires</term><term>Femelle</term><term>Ghana (épidémiologie)</term><term>Gènes env</term><term>Gènes gag (génétique)</term><term>Gènes pol</term><term>Gènes viraux</term><term>Génotype</term><term>Humains</term><term>Infections à VIH (virologie)</term><term>Infections à VIH (épidémiologie)</term><term>Mâle</term><term>Phylogénie</term><term>RT-PCR</term><term>Recombinaison génétique</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) ()</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique)</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (isolement et purification)</term><term>VIH-2 (Virus de l'Immunodéficience Humaine de type 2) ()</term><term>VIH-2 (Virus de l'Immunodéficience Humaine de type 2) (génétique)</term><term>VIH-2 (Virus de l'Immunodéficience Humaine de type 2) (isolement et purification)</term><term>Virémie</term><term>Épidémiologie moléculaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Ghana</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>HIV-1</term><term>HIV-2</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genes, gag</term><term>HIV-1</term><term>HIV-2</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Gènes gag</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term><term>VIH-2 (Virus de l'Immunodéficience Humaine de type 2)</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>HIV-1</term><term>HIV-2</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>ARN viral</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term><term>VIH-2 (Virus de l'Immunodéficience Humaine de type 2)</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Ghana</term><term>Infections à VIH</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Epidémiologie moléculaire</term><term>Ghana</term><term>Génotype</term><term>SIDA</term><term>Virus immunodéficience humaine</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Adult</term><term>Aids patients</term><term>Asymptomatic</term><term>Asymptomatic candidate blood donors</term><term>Asymptomatic candidate donors</term><term>Asymptomatic population</term><term>Biosystem</term><term>Carr</term><term>Clinical aids</term><term>Clinical status</term><term>Cluster Analysis</term><term>Cornelissen</term><term>Delaporte</term><term>Double infection</term><term>Double infections</term><term>Dual infections</term><term>Epidemiology</term><term>Female</term><term>Genes, Viral</term><term>Genes, env</term><term>Genes, pol</term><term>Genetic diversity</term><term>Genome</term><term>Genotype</term><term>Ghana</term><term>Heteroduplex mobility assay</term><term>Heyndrickx</term><term>Human virus type</term><term>Humans</term><term>Hxb2</term><term>Hxb2 positions</term><term>Inner primers</term><term>Ishikawa</term><term>Janssens</term><term>Kumasi</term><term>Male</term><term>Mboup</term><term>Mccutchan</term><term>Middle Aged</term><term>Molecular Epidemiology</term><term>Molecular Sequence Data</term><term>Molecular data</term><term>Molecular distribution</term><term>Molecular epidemiology</term><term>Molecular groups</term><term>Montavon</term><term>Nucleic acid</term><term>Outer primers</term><term>Peeters</term><term>Phylogenetic</term><term>Phylogenetic analysis</term><term>Phylogeny</term><term>Present study</term><term>Primer</term><term>Protease gene</term><term>Recombinant</term><term>Recombinant form</term><term>Recombinant forms</term><term>Recombinant strains</term><term>Recombination</term><term>Recombination, Genetic</term><term>Reference strains</term><term>Retrovirus</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Sample collection</term><term>Second round</term><term>Sequence Analysis, DNA</term><term>Sequencing</term><term>Subtype</term><term>Subtypes</term><term>Total population</term><term>Vergne</term><term>Viral</term><term>Viremia</term><term>West africa</term><term>West african countries</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de regroupements</term><term>Analyse de séquence d'ADN</term><term>Données de séquences moléculaires</term><term>Femelle</term><term>Ghana</term><term>Gènes env</term><term>Gènes pol</term><term>Gènes viraux</term><term>Génotype</term><term>Humains</term><term>Mâle</term><term>Phylogénie</term><term>RT-PCR</term><term>Recombinaison génétique</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term><term>VIH-2 (Virus de l'Immunodéficience Humaine de type 2)</term><term>Virémie</term><term>Épidémiologie moléculaire</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>épidémiologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent studies showed the importance of CRF02_AG in West Africa, although the clinical relevance of these recombinant forms of HIV remains unknown. The present study aimed at determining the molecular diversity of HIV in Ghana and investigating the possible epidemiologic advantage of recombinant HIV‐1. Plasma samples collected in 1999–2002 from two populations of HIV infected individuals (144 asymptomatic candidate blood donors and 169 AIDS patients) were studied and 249 of them were molecularly characterised in gag, pol, and env regions. Five molecular groups were identified: strains clustering with CRF02_AG in all regions (147/249 or 59%), recombinant strains clustering with CRF02_AG in one or two regions (50/249 or 20%), other subtypes, pure or recombinant, but not involving CRF02_AG (37/249 or 15%), HIV‐2 (11/249 or 4.5%), and double infections (4/249 or 1.5%). There was no significant difference in the distribution of HIV‐1 recombinant strains according to clinical presentation. No evidence of a significant increase in CRF02_AG prevalence between 1999 and 2002 was found. Irrespective of clinical condition, CRF02_AG is the predominant molecular form of HIV‐1 in Kumasi, Ghana. J. Med. Virol. 73:158–166, 2004. © 2004 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Ghana</li><li>Royaume-Uni</li></country><region><li>Angleterre</li></region></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Fischetti, Lucia" sort="Fischetti, Lucia" uniqKey="Fischetti L" first="Lucia" last="Fischetti">Lucia Fischetti</name></region><name sortKey="Allain, Jean Pierre" sort="Allain, Jean Pierre" uniqKey="Allain J" first="Jean Pierre" last="Allain">Jean Pierre Allain</name><name sortKey="Allain, Jean Pierre" sort="Allain, Jean Pierre" uniqKey="Allain J" first="Jean Pierre" last="Allain">Jean Pierre Allain</name><name sortKey="Candotti, Daniel" sort="Candotti, Daniel" uniqKey="Candotti D" first="Daniel" last="Candotti">Daniel Candotti</name><name sortKey="Lee, Helen" sort="Lee, Helen" uniqKey="Lee H" first="Helen" last="Lee">Helen Lee</name></country><country name="Ghana"><noRegion><name sortKey="Opare Em, Ohene" sort="Opare Em, Ohene" uniqKey="Opare Em O" first="Ohene" last="Opare-Sem">Ohene Opare-Sem</name></noRegion><name sortKey="Sarkodie, Francis" sort="Sarkodie, Francis" uniqKey="Sarkodie F" first="Francis" last="Sarkodie">Francis Sarkodie</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaGhanaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F49 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000F49 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= SidaGhanaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:BEDA12C23AA0858C475661CF3A8D230FF53EADD5
|texte= Molecular epidemiology of HIV in Ghana: Dominance of CRF02_AG
}}
| This area was generated with Dilib version V0.6.31. |  |